As with CGE's Space Alert, Alchemists adds a bit of technology to the more familiar game bits that you'll find in the box, with the goal being to prevent this deduction-based game from ever falling prey to the risk of a player mistake ruining the experience for everyone. Now, a player mistake will simply ruin the experience for that player — a much better result! For those averse to videos, here's a written description of the game:
But what arcane secrets do these strange ingredients hide? Now it is time to find out. Mix them into potions and drink them to determine their effects — or play it safe and test the concoction on a helpful student! Gain riches selling potions to wandering adventurers and invest these riches in powerful artifacts. As your knowledge grows, so will your reputation, as you publish your theories for all to see. Knowledge, wealth, and fame can all be found in the murky depths of the alchemist's cauldron.
In Alchemists, two to four budding alchemists compete to discover the secrets of their mystical art. Points can be earned in various ways, but most points are earned by publishing theories – correct theories, that is — and therein lies the problem.
The game is played in six rounds. At the beginning of the round, players choose their play order. Those who choose to play later get more rewards.
Players declare all their actions by placing cubes on the various action spaces, then each action space is evaluated in order. Players gain knowledge by mixing ingredients and testing the results using a smartphone app that randomizes the rules of alchemy for each new game. Players can also earn money by selling potions to adventurers, but money is just a means to an end. The alchemists don't want riches, after all. They want respect, and respect usually comes from publishing theories.
During play, players' reputations will go up and down. After six rounds, this reputation will be converted into points. Points will also be scored for artifacts and grants, and several bonuses will be handed out. Then the secrets of alchemy are revealed and players score points or lose points based on whether their theories were correct.
Whoever has the most points at the end of the game wins.