Cortes: Conquest of the Aztec Empire (1993)

A two-player wargame that covers the epic three month siege of Tenochtitlan, the climactic battle for control of Mexico, fought in 1521.
14 pages of rules, 144 5/8" counters, and a 22" x 34" map are included.

This game is the only one that I am aware of that includes rules for Human Sacrifice...

If Cortes is killed or captured, the Aztec player wins immediately. Otherwise, the Spanish player must keep his "Loss Points" to a minimum... as long as the Spanish player does not gain 17 or more points, they win.