While the original Pandemic design might not have been thought of as a formula or framework for future designs, Leacock and others have transformed it into one, with the heart of each Pandemic game being the brilliant use of the infection deck. Whenever an epidemic strikes, you inject a new location on the game board with something terrible, then you shuffle all of the revealed location cards and place them back on top of the infection deck, ready to be revealed again to escalate your current woes. You know where bad things will happen; you just don't know when and in which order. That simple mechanism mimics the behavior of actual epidemics, not to mention other catastrophes, to present players with a challenge that's simultaneously frightening and manageable.
Pandemic Iberia, co-designed with Jesús Torres Castro and published by Z-Man Games, uses this familiar formula, while adding historic twists appropriate to the game's setting in the mid-19th century. Air travel is out, while travel by train is in — assuming that you build the rails first, that is. You're not able to cure diseases outright, but you can at least research these diseases and lay the groundwork for future creative efforts by others, similar to how the original Pandemic has laid the groundwork for this creation, Pandemic: Reign of Cthulhu, and other titles still to come.